final_model_kif14_small

Article indentifying kinesin KIF14 as a new regulator of cilia formation and function

Study led by Petra Pejšková from a group of Lukas Cajanek, entitled: KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling  has been accepted for publication in Journal of Cell Biology. This work shows for the first time kinesin KIF14 localizes to primary cilia and is required for its correct formation – cilia form at reduced rate Read more about Article indentifying kinesin KIF14 as a new regulator of cilia formation and function[…]

mboc_teaser

Publication on identification and characterisation of TTBK2-driven phosphorylations during ciliogenesis

Study led by Ondrej Bernatik from a group of Lukas Cajanek, entitled: Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2  has been accepted for publication in Mol Biol Cell. This work identifies several novel substrates and many new target sites of TTBK2 and hence provides valuable insight into the molecular control of Read more about Publication on identification and characterisation of TTBK2-driven phosphorylations during ciliogenesis[…]

centrosome_wnt

Review on centrosomes, cell cycle, and Wnt signaling

Review article written by Lukas Cajanek (our department) , Vitezslav Bryja (MU, Faculty of Science), and Igor Cervenka (Karolinska Institute, Sweden), entitled: The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? was accepted in Critical Reviews in Biochemistry and Molecular Biology.     Wnt signaling cascade has developed together with Read more about Review on centrosomes, cell cycle, and Wnt signaling[…]