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Publication on the role of FGF and WNT signaling in lung organoid formation

A study by Anas Rabata, a collaborative effort of Ales Hampl and Zuzana Koledova groups, entitled “3D cell culture models demonstrate a role for FGF and WNT signaling in regulation of lung epithelial cell fate and morphogenesis”, was accepted for publication in Frontiers in Cell and Developmental Biology. This study reveals distinct roles for FGF Read more about Publication on the role of FGF and WNT signaling in lung organoid formation[…]

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Success at the national level of competition in Secondary School Research

Congratulations to Ema Grofová, who won 2nd place at the national level of competition in Secondary School Research for her work entitled “Testing the effect of fibroblast growth factors on development of mammary gland in 3D cultures”! Ema is a high-school student from Gymnázium Matyáše Lercha in Brno, and she has been mentored by Zuzana Read more about Success at the national level of competition in Secondary School Research[…]

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Article indentifying kinesin KIF14 as a new regulator of cilia formation and function

Study led by Petra Pejšková from a group of Lukas Cajanek, entitled: KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling  has been accepted for publication in Journal of Cell Biology. This work shows for the first time kinesin KIF14 localizes to primary cilia and is required for its correct formation – cilia form at reduced rate Read more about Article indentifying kinesin KIF14 as a new regulator of cilia formation and function[…]

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Publication on identification and characterisation of TTBK2-driven phosphorylations during ciliogenesis

Study led by Ondrej Bernatik from a group of Lukas Cajanek, entitled: Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2  has been accepted for publication in Mol Biol Cell. This work identifies several novel substrates and many new target sites of TTBK2 and hence provides valuable insight into the molecular control of Read more about Publication on identification and characterisation of TTBK2-driven phosphorylations during ciliogenesis[…]

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Publication on the intricacies of FGF signaling

The fruitful collaboration between the Koledova group, the Loschmidt laboratories and the biotechnology company Enantis has brought a new publication. Using hyperstable variants of FGF2, the authors led by Zuzana Koledova elucidate some of the intricacies of FGF signaling. The article entitled „Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction Read more about Publication on the intricacies of FGF signaling[…]

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Review on centrosomes, cell cycle, and Wnt signaling

Review article written by Lukas Cajanek (our department) , Vitezslav Bryja (MU, Faculty of Science), and Igor Cervenka (Karolinska Institute, Sweden), entitled: The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? was accepted in Critical Reviews in Biochemistry and Molecular Biology.     Wnt signaling cascade has developed together with Read more about Review on centrosomes, cell cycle, and Wnt signaling[…]

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New book “Guide to General Histology and Microscopic Anatomy” by Petr Vaňhara, Miroslava Sedláčková, Irena Lauschová, Svatopluk Čech, and Aleš Hampl was released!

We are happy to announce that brand new study tool, “Guide to General Histology and Microscopic Anatomy” was just released. The Guide is contains hundreds of original, high-quality microphotographs and electronograms, annotated with contemporary terminology, assembled into separable write-and-wipe panels. Available since March 2017 in the Campus bookstore.