Research Interests | PhD position | Grants | Team Members | Publications
Ing. Josef Jaroš, Ph.D.
Assistant Professor
- E-mail: jaros@med.muni.cz
- Phone: +420 549 49 6248
Group leader, Researcher at - Masaryk University, Faculty of Medicine, Brno, CZ
- Cell & Tissue Regeneration, FNUSA-ICRC, Brno, CZ
Experiences from - Karolinska Institutet, Stockholm, Sweden
- Max Planck Institute, Dresden, Germany
- University of Kuopio, Kuopio, Finland
- Université Joseph Fourier, Grenoble, France
Research interests
Our group is focused on creating models of lung and neural tissues and related diseases. Research includes the development of: (i) tissue models; (ii) engineered 3D cell culture platforms; (iii) tools to study stem cell differentiation and how cells communicate; (iv) 3D bioprinting of stem cells and hydrogels; (v) microfluidic systems for long-term 3D cultivation and studies of tissue morphogenesis and (vi) 3D angiogenesis. As excellent developmental model we utilize human embryonic stem cells and their derivatives as well as pluripotent stem cells induced from primary cells of patients. We are targeting unresolved aspects of tissue formation, cell-cell and cell-ECM interactions, stem cell biology & differentiation utilizing state-of-the-art instrumentation, molecular and cell biology, histochemistry and cell imaging.
Opened Bc., MSc., PhD Position
We are currently looking for motivated students for running research interested in developmental biology and tissue engineering. Join our progressive team of friendly people and participate in international collaborations. (leaflet)
Funding
Standard Research Grant, Czech Science Foundation, 2021-2023
Student grant (Vaclav Chochola), MU Internal Grant Agency, 2021
Standard Research Grant, Czech Science Foundation, 2018-2020
PhD talent (Vaclav Chochola), Brno City Municipality, 2018-2021
Operational programme Research, Development and Education (in Czech OP VVV)), Ministry of Education, Youth and Sports, 2018-2022
Interdisciplinary research project, Masaryk University Faculty of Medicine, 2015. (info)
Team members
Josef Jaros, group leader
Ivana Acimovic, postdoc
Jakub Pospisil, PhD student
Mario Kandra, PhD student
Vaclav Chochola, PhD student
Barbora Olivova, MSc student
Marie Ptackova, BSc student
Jan Bilek, BSc student
Veronika Valouchova, MD student, P-Pool
Publications
2019
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SEDLÁKOVÁ, Veronika, Michaela KLOUČKOVÁ, Zuzana GARLÍKOVÁ, Kateřina VAŠÍČKOVÁ, Josef JAROŠ, Mário KANDRA, Hana KOTASOVÁ a Aleš HAMPL. Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips. Drug Discovery Today, Oxford (England): Elsevier Sci Ltd., 2019, roč. 24, č. 4, s. 971-982. ISSN 1359-6446. doi:10.1016/j.drudis.2019.03.006.
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POSPÍŠIL, Jakub, Josef LAVICKÝ, Ilya KOTELNIKOV, Vladimír PROKS, Aleš HAMPL a Josef JAROŠ. Synthetic cell culture environment for propagation and differentiation of human pluripotent stem cells. In XIX. Interdisciplinary meeting of young life scientists, Milovy, 20.5-23.5.2019, 2019. 2019.
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KANDRA, Mário, Jakub POSPÍŠIL, Václav CHOCHOLA, Aleš HAMPL a Josef JAROŠ. Microfluidic chip as a tool for uniform generation of spheroids. In Organ-on-a-Chip & Tissue-on-a-Chip Europe, 18-19.6.2019, Rotterdam, NL. 2019.
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CHOCHOLA, Václav, Karolína SPUSTOVÁ, Richard MACKOVIČ, Josef LAVICKÝ, Mário KANDRA, Jakub POSPÍŠIL, Vladimír PROKS, Aleš HAMPL a Josef JAROŠ. Modification of alginate-based bioinks for 3D printing and stem cell cultivation. In XIX. Interdisciplinary meeting of young life scientists, Milovy, 20.5-23.5.2019, 2019. 2019. 2019. ISSN 2336-7210.
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HOVÁDKOVÁ, Zuzana, Milos HRABOVSKÝ, Rostislav VÁŇA, Jakub POSPÍŠIL, Josef JAROŠ, Jiří DAMBORSKÝ, Kamil PARUCH a Aleš HAMPL. Nanopatterning Glass Surface For Localization Of Embryonic Stem Cells. In Microscopy Conference, 1-5.9.2019, Berlin, Germany. 2019.
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VIČAR, Tomáš, Jan BALVAN, Josef JAROŠ, Florian JUG, Radim KOLAR, Michal MASAŘÍK a Jaromír GUMULEC. Cell segmentation methods for label-free contrast microscopy: review and comprehensive comparison. BMC Bioinformatics, London: BioMed Central, 2019, roč. 20, č. 360, s. 1-25. ISSN 1471-2105. doi:10.1186/s12859-019-2880-8.
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KUČÍREK, Martin, Alireza Jian BAGHERPOOR, Josef JAROŠ, Aleš HAMPL a Michal ŠTROS. HMGB2 is a negative regulator of telomerase activity in human embryonic stem and progenitor cells. FASEB Journal, Federation of American Societies for Experimental Biology, 2019, roč. 2019, č. 12, s. 14307-14324. ISSN 0892-6638. doi:10.1096/fj.201901465RRR.
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KANDRA, Mário, Jakub POSPÍŠIL, Aleš HAMPL a Josef JAROŠ. Microfluidic chip as a tool for uniform spheroid generation. In XIX. Interdisciplinary meeting of young life scientists, Milovy, 20-23.5.2019. 2019.
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BOUDNÝ, Miroslav, Jana ZEMANOVÁ, PrashantKumar KHIRSARIYA, Marek BORSKÝ, Jan VERNER, Jana ČERNÁ, Alexandra OLTOVA, Václav ŠEDA, Marek MRÁZ, Josef JAROŠ, Zuzana JAŠKOVÁ, Michaela ŠPUNAROVÁ, Yvona BRYCHTOVÁ, Karel SOUČEK, Stanislav DRÁPELA, Marie KAŠPÁRKOVÁ, Jiří MAYER, Kamil PARUCH a Martin TRBUŠEK. Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. Haematologica, PAVIA: FERRATA STORTI FOUNDATION, 2019, roč. 104, č. 12, s. 2443-2455. ISSN 0390-6078. doi:10.3324/haematol.2018.203430.
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ANDRAŠINA, Tomáš, Josef JAROŠ, Tomáš JŮZA, Tomáš ROHAN, Dalibor ČERVINKA, Michal CRHA, Vlastimil VÁLEK a Nahum S. GOLDBERG. The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models. Cardiovascular and Interventional Radiology, NEW YORK: SPRINGER, 2019, roč. 42, č. 5, s. 751-762. ISSN 0174-1551. doi:10.1007/s00270-019-02175-z.
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JAROŠ, Josef, Václav CHOCHOLA, Karolína SPUSTOVÁ, Mário KANDRA, Jakub POSPÍŠIL, Vladimír PROKS a Aleš HAMPL. 3D bioprinting of stem cells for creating tissue models. In 10th International Conference Analytical Cytometry. 2019.
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CHOCHOLA, Václav, Karolína SPUSTOVÁ, Richard MACKOVIČ, Mário KANDRA, Jakub POSPÍŠIL, Vladimír PROKS, Aleš HAMPL a Josef JAROŠ. 3D-bioprinting and cell culture with modified alginate bioinks. In Biofabrication & Biomanufacturing Europe, 20-21.6.2019, Rotterdam, NL. 2019.
2018
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GOLAN, Martin, Jan PŘIBYL, Martin PEŠL, Šárka JELÍNKOVÁ, Ivana AĆIMOVIĆ, Josef JAROŠ, Vladimír ROTREKL, Martin FALK, Ludek SEFC, Petr SKLÁDAL a Irena KRATOCHVILOVA. Cryopreserved Cells Regeneration Monitored by Atomic Force Microscopy and Correlated With State of Cytoskeleton and Nuclear Membrane. IEEE TRANSACTIONS ON NANOBIOSCIENCE, PISCATAWAY: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2018, roč. 17, č. 4, s. 485-497. ISSN 1536-1241. doi:10.1109/TNB.2018.2873425.
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JAROŠ, Josef, Josef LAVICKÝ, Jakub POSPÍŠIL, Ilya N. KOTELNIKOV, Vladimír PROKS a Aleš HAMPL. Effect of synthetic surface modifications on behavior of pluripotent stem cells. In 8th Annual meeting on stem cells, DNA damage and apoptosis, Karlov, 31.1.-3.2.2018. 2018