Research | Publications | Funding | Team Members | Collaborations | Lab web | News
Our key questions:
- How does a human cell control formation of primary cilia at molecular level ?
- What are consequences of centriole abnormalities for stem cells and their differentiated progeny ?
If you want to know more about what we do, please visit our Lab web
If you are interested in studying the mysteries of cilia and centrioles, please contact me (Lukas Cajanek) ahead of time with brief description of research interests and CV. Motivated undergraduate students are encouraged to inquire about short term projects available in the lab.
Bernatik O, Paclikova P, Kotrbova A, Bryja V, Cajanek L. Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling. 2021. Frontiers in Cell and Developmental Biology.
Pejskova P, Reilly ML, Bino L, Bernatik O, Dolanska L, Ganji RS, Zdrahal Z, Benmerah A, Cajanek L. KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling. 2020. Journal of Cell Biology.
Bernatik O, Pejskova P, Vyslouzil D, Hanakova K, Zdrahal Z, Cajanek L. Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2. Mol Biol Cell, 2020. full text
Renzová T, Bohačiaková D, Ešner M, Pospíšilová V, Bárta T, Hampl A, Čajánek L. Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells. Stem Cell Reports, 2018. full text
Bryja V, Červenka I, Čajánek L. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? Crit Rev Biochem Mol Biol., 2017. review article. full text
Čajánek L, Glatter T, Nigg EA. The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis. J Cell Sci., 2015. full text
Čajánek L, Nigg EA. Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole. Proc Natl Acad Sci U S A., 2014. full text
Nigg EA, Čajánek L, Arquint C. The centrosome duplication cycle in health and disease. FEBS Lett., 2014, review. full text
Bhogaraju S, Čajánek L, Fort C, Blisnick T, Weber K, Taschner M, Mizuno N, Lamla S, Bastin P, Nigg EA, Lorentzen E. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science, 2013. full text
Čajánek L, Ganji RS, Henriques-Oliveira C, Theofilopoulos S, Koník P, Bryja V, Arenas E. Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol Cell Biol., 2013. full text
Čajánek L, Ribeiro D, Liste I, Parish CL, Bryja V, Arenas E. Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells. Stem Cells, 2009. full text
For a complete list of publications go to PubMed
Standard Research Grant, Czech Science Foundation, 2021-2024. (more info).
Standard Research Grant, Czech Science Foundation, 2019-2021. (more info).
Promotion of Young Scientists in Eastern Europe (PROMYS), Swiss National Science Foundation, 2017-2021. (more info)
Junior research grant, Czech Science Foundation, 2016-2018. (more info)
FEBS follow-up reseach fund, Federation of European Biochemical Societes, 2016-2017. (more info)
Start-up grant for newly recruited personel, Masaryk University Faculty of Medicine, 2015. (more info)
Distinguished Young Investigator Award, Federation of European Biochemical Societes, 2015. (more info)
SoMoPro, Marie-Currie actions & South Moravian region, 2014-2016. (more info)
Lukáš Čajánek, PI. (info)
Iva Pernicová, lab manager. (info)
Ondřej Bernatík, postdoc. (info)
Lucia Binó, postdoc. (info)
Tereza Renzová, postdoc. (info)
Erika Mikulenková, postdoc. (info)
Petra Pejšková, maternity leave. (info)
David Vysloužil, PhD student.(info)
Vítězslav Bryja, Masaryk University Brno, Faculty of Science. (info)
Zbyněk Zdráhal, Masaryk University Brno, Central European Institute of Technology (CEITEC). (info)
Vladimír Varga, Institute of Molecular Genetics of the Academy of Sciences. (info)
Friedhelm Hildebrandt, Harvard Medical School & Boston Children’s Hospital (info)
Alexandre Benmerah, Imagine Institute & Paris University (info)
Mark van Breugel, Queen Mary University London (info)
Martina Huranová, Institute of Molecular Genetics of the Academy of Sciences (info)