November 1, 2016

Lukáš Čajánek Team

Research | Publications | Funding | Team Members | Collaborations | Lab web





Our key questions:

  • How does a human cell control formation of primary cilia at molecular level ?
  • What are consequences of centriole abnormalities for stem cells and their differentiated progeny ?

If you want to know more about what we do, please visit our Lab web





Selected publications


Renzová T, Bohačiaková D, Ešner M, Pospíšilová V, Bárta T, Hampl A, Čajánek L. Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells. Stem Cell Reports, 2018. full text

Bryja V, Červenka I, Čajánek L. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? Crit Rev Biochem Mol Biol., 2017. review article. full text

Čajánek L, Glatter T, Nigg EA. The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis. J Cell Sci., 2015. full text

Čajánek L, Nigg EA. Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole. Proc Natl Acad Sci U S A., 2014. full text

Nigg EA, Čajánek L, Arquint C. The centrosome duplication cycle in health and disease. FEBS Lett., 2014, review. full text

Bhogaraju S, Čajánek L, Fort C, Blisnick T, Weber K, Taschner M, Mizuno N, Lamla S, Bastin P, Nigg EA, Lorentzen E. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science, 2013. full text

Čajánek L, Ganji RS, Henriques-Oliveira C, Theofilopoulos S, Koník P, Bryja V, Arenas E. Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol Cell Biol., 2013. full text

Čajánek L, Ribeiro D, Liste I, Parish CL, Bryja V, Arenas E. Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells. Stem Cells, 2009. full text

For a complete list of publications go to PubMed



Standard Research Grant, Czech Science Foundation, 2019-2021. (more info).

Promotion of Young Scientists in Eastern Europe (PROMYS)Swiss National Science Foundation, 2017-2021. (more info)

Junior research grant, Czech Science Foundation, 2016-2018. (more info)

FEBS follow-up reseach fund, Federation of European Biochemical Societes, 2016-2017. (more info)

Start-up grant for newly recruited personel, Masaryk University Faculty of Medicine, 2015. (more info)

Distinguished Young Investigator Award, Federation of European Biochemical Societes, 2015. (more info)

SoMoPro, Marie-Currie actions & South Moravian region, 2014-2016. (more info)


Team members



Lukáš Čajánek, PI. (info)

Barbora Valnohová, lab manager. (info)

Ondřej Bernatík, postdoc. (info)

Lucia Binó, postdoc. (info)

Tereza Renzová, PhD student. (info)

Petra Kovaříková, PhD student. (info)

David Vysloužil, bachelor student.

Linda Dolanská, bachelor student.






Vítězslav Bryja, Masaryk University Brno, Faculty of Science. (info)

Zbyněk Zdráhal, Masaryk University Brno, Central European Institute of Technology (CEITEC). (info)

Vladimír Varga, Institute of Molecular Genetics of the Academy of Sciences. (info)

Friedhelm Hildebrandt, Harvard Medical School & Boston Children’s Hospital (info)