Department of Biology | Faculty of Medicine | Masaryk University | Czech Republic

Laboratory of Recombination
and DNA Repair (LORD)

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Publications

2021

2020

2019

2018

• Sinha D, Bialevich V, Shamayeva K, Guzanova A, Sisakova A, Csefalvay E, Reha D, Krejci L, Carey J, Weiserova M, Ettrich R. A residue of motif III positions the helicase domains of motor subunit HsdR in restriction-modification enzyme EcoR124I. J Mol Model. 2018 Jun 26;24(7):176. doi: 10.1007/s00894-018-3722-8.

• Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P. SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature. 2018 Apr 18. doi: 10.1038/s41586-018-0050-1.

• Špírek M, Mlcoušková J, Belán O, Gyimesi M, Harami GM, Molnár E, Novacek J, Kovács M, Krejci L. Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state. Nucleic Acids Res. 2018 Feb 22. doi: 10.1093/nar/gky111.

2017

• Zadorozhny K, Sannino V, Beláň O, Mlčoušková J, Špírek M, Costanzo V, Krejčí L. Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection. Cell Rep. 2017 Oct 10;21(2):333-340. doi: 10.1016/j.celrep.2017.09.062.

• Sisakova A, Altmannova V, Sebesta M, Krejci L. Role of PCNA and RFC in promoting Mus81-complex activity. BMC Biol. 2017 Oct 2;15(1):90. doi: 10.1186/s12915-017-0429-8.

• Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L, Costanzo V. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. Mol Cell. 2017 Jul 20. pii: S1097-2765(17)30495-1. doi: 10.1016/j.molcel.2017.07.001.

• Samadder P, Suchanková T, Hylse O, Khirsariya P, Nikulenkov F, Drápela S, Straková N, Vaňhara P, Vašíčková K, Kolářová H, Binó L, Bittová M, Ovesná P, Kollar P, Fedr R, Ešner M, Jaroš J, Hampl A, Krejčí L, Paruch K, Soucek K. Synthesis and profiling of a novel potent selective inhibitor of CHK1 kinase possessing unusual N-trifluoromethylpyrazole pharmacophore resistant to metabolic N-dealkylation. Mol Cancer Ther. 2017 Jun 15. pii: molcanther.0018.2017. doi: 10.1158/1535-7163.MCT-17-0018.

• Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, Hühn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L, Janscak P. RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Mol Cell. 2017 Jun 1;66(5):658-671.e8. doi: 10.1016/j.molcel.2017.05.006.

• Shemesh K, Sebesta M, Pacesa M, Sau S, Bronstein A, Parnas O, Liefshitz B, Venclovas C, Krejci L, Kupiec M. A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance. Nucleic Acids Res. 2017 Apr 7;45(6):3189-3203. doi: 10.1093/nar/gkw1348.

• Parvanov ED, Tian H, Billings T, Saxl RL, Spruce C, Aithal R, Krejci L, Paigen K, Petkov PM. PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Mol Biol Cell. 2017 Feb 1;28(3):488-499. doi: 10.1091/mbc.E16-09-0686.

• Vasianovich Y, Altmannova V, Kotenko O, Newton MD, Krejci L, Makovets S. Unloading of homologous recombination factors is required for restoring double-stranded DNA at damage repair loci. EMBO J. 2017 Jan 17;36(2):213-231. doi: 10.15252/embj.201694628.

• Sebesta M, Urulangodi M, Stefanovie B, Szakal B, Pacesa M, Lisby M, Branzei D, Krejci L. Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains. Nucleic Acids Res. 2017 Jan 9;45(1):215-230. doi: 10.1093/nar/gkw882.

2016

• Taylor MR, Špírek M, Jian Ma C, Carzaniga R, Takaki T, Collinson LM, Greene EC, Krejci L, Boulton SJ. A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling. Mol Cell. 2016 Dec 1;64(5):926-939. doi: 10.1016/j.molcel.2016.10.020.

• Shyamsunder P, Esner M, Barvalia M, Wu YJ, Loja T, Boon HB, Lleonart ME, Verma RS, Krejci L, Lyakhovich A. Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission. Oncotarget. 2016 Sep 6;7(36):58065-58074. doi: 10.18632/oncotarget.11161.

• Silva S, Altmannova V, Eckert-Boulet N, Kolesar P, Gallina I, Hang L, Chung I, Arneric M, Zhao X, Buron LD, Mortensen UH, Krejci L, Lisby M. SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination. (2016) DNA Repair. 42: 11-25. DOI: 10.1016/j.dnarep.2016.04.001

• Silva S, Altmannova V, Luke-Glaser S, Henriksen P, Gallina I, Yang X, Choudhary Ch, Luke B, Krejci L, Lisby M. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. (2016) Genes Dev. 30: 700-717. DOI: 10.1101/gad.276204.115

• Kolesar P, Altmannova V, Silva S, Lisby M, Krejci L. (2016) Pro-recombination Role of Srs2 Protein Requires SUMO (Small Ubiquitin-like Modifier) but Is Independent of PCNA (Proliferating Cell Nuclear Antigen) Interaction. J Biol Chem. 291: 7594-7607. DOI: 10.1074/jbc.M115.685891

• Burkovics P, Dome L, Juhasz S, Altmannova V, Sebesta M, Pacesa M, Fugger K, Sorensen CS, Lee M, Haracska L, Krejci L. (2016) The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis. (2016) Nucleic Acid Res. 44 (7): 3176-3189. DOI: 10.1093/nar/gkw024

• Pevala V, Truban D, Bauer JA, Kostan J, Kunová N, Bellova J, Brandstetter M, Marini V, Krejci L, Tomaska L, Nosek J, Kutejová E. (2016) The structure and DNA-binding properties of Mgm101 from a yeast with a linear mitochondrial genome. Nucleic Acid Res. 44 (5): 2227-2239. DOI: 10.1093/nar/gkv1529

• Bakkaiova J, Marini V, Willcox S, Nosek J, Griffithv JD, Krejci L, Tomaska L (2016) Yeast mitochondrial HMG proteins: DNA-binding properties of the most evolutionarily divergent component of mitochondrial nucleoids. Biosci Rep. 36 (1) DOI: 10.1042/BSR20150275

2015

• Zemanova J, Paruch K, Krejci L, Soucek K, Hylse O, Boudny M, Borsky M, Osickova J, Khirsariya P, Sebejova L, Navrkalova V, Malcikova J, Diviskova E, Brychtova Y, Mayer J, Trbusek M (2015) Chronic lymphocytic leukemia cells are highly susceptible to direct inhibition of checkpoint kinase. HAEMATOLOGICA 100 (1) 417-417 E1048. IF: 5.814

• Kliszczak M, Sedlackova H, Pitchai GP, Streicher WW, Krejci L, Hickson, ID. (2015) Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells. Oncotarget 6 (38): 40464. IF: 6.359

• Urulangodi M, Sebesta M, Menolfi D, Szakal B, Sollier J, Sisakova A, Krejci L, Branzei D (2015) Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication. GENES & DEVELOPMENT 29 (19) 2067-2080. DOI: 10.1101/gad.265629.115, IF: 10.798

• Vrbsky J, Tereh T, Kyrylenko S, Dvorak P, Krejci L (2015) MEK and TGF-beta Inhibition Promotes Reprogramming without the Use of Transcription Factor. PLOS ONE 10 (6) e0127739. DOI: 10.1371/journal.pone.0127739, IF: 3.234

• Sebesta M, Krejci L (2015) Phosphorylation of Elg1 regulates its activity. CELL CYCLE 14 (19) 3009-3010. DOI: 10.1080/15384101.2015.1084199, IF: 4.565

• Taylor MRG, Spirek M, Carasiya KR, Ward JD, Carzaniga R, Yu X, Egelman EH, Collinson LM, Rueda D, Krejci L, Boulton SJ. (2015) Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination. Cell Press. 162 (2) 271-286. DOI: 10.1016/j.cell.2015.06.015, IF: 32.242

• Sedlackova H, Cechova B, Mlcouskova J, and Krejci L (2015) RECQ4 selectively recognizes Holliday junctions. DNA Repair 30, 80-89. DOI: 10.1016/j.dnarep.2015.02.020, IF: 3.111

• Chavdarova M, Sisakova A, Marini V, Sedlackova H, Vigasova D, Brill S, Lisby M, and Krejci L (2015) Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates. Nucleic Acid Res. 43 (7), 3626-3642. DOI: 10.1093/nar/gkv198, IF: 9.112

• Sarangi P, Steinacher R, Altmannova V, Fu Q, Paull TT, Krejci L, Whitby MC, and Zhao X (2015) Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein. PLoS Genet. 11(1): e1004899. DOI: 10.1371/journal.pgen.1004899, IF: 7.528

• Bologna S, Altmannova V, Valtorta E, Koenig C, Liberali P, Gentili C, Anrather D, Ammerer G, Pelkmans L, Krejci L, Ferrari S (2015) Sumoylation regulates EXO1 stability and processing of DNA damage. CELL CYCLE 14 (15) 2439-2450 DOI: 10.1080/15384101.2015.1060381, IF: 4.565

2014

• Sarangi P, Altmannova V, Holland C, Bartosova, Z, Hao F, Anrather D., Ammerer G, Lee SE, Krejci L, and Zhao X (2014) A versatile scaffold contributes to damage survival via sumoylation and nuclease interactions. Cell Rep. 9(1) 143-52. DOI: 10.1016/j.celrep.2014.08.054, IF: 8.358

• Krejci L, Nikulenkov F, Sisakova A, Samadder P, Suchankova T, Chavdarova M, Daniel L, Brezovsky J, Janscak P, Damborsky J, Soucek K, Paruch K (2014) DNA damage response proteins as a pharmacological targets. FEBS Journal 281 50-50. CS-V-3-5 IF: 4.001

• Burkovics P, Sebesta M, Balogh D. Haracska L, Krejci L (2014) Strand invasion by HLTF as a mechanism for template switch in fork rescue. Nucleic Acid Res. 42(3) 61711-20. DOI: 10.1093/nar/gkt1040, IF: 9.112

• Zálešák J, Lourdin M, Krejčί L, Constant J and Jourdan M, (2014) Structure and dynamics of DNA duplexes containing a cluster of mutagenic 8-oxoguanine and abasic site lesions. J. Mol. Biol. 426 (7), 1524-38. DOI: 10.1016/j.jmb.2013.12.022, IF: 4.333

• Sarangi P, Bartosova Z, Altmannova V, Holland C, Cavdarova M, Lee SE, Krejci L, and Zhao X (2014) Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association. Nucleic Acid Res. 42(10) 6393-404. DOI: 10.1093/nar/gku300 IF: 9.112

2013

• Vigasova D, Sarangi P, Kolesar P, Vlasakova D, Slezakova Z, Altmannova V, Nikulenkov F, Anrather D, Gith R, Zhao X, Chovanec M, and Krejci L (2013) Lif1 SUMOylation and its role in non-homologous end-joining. Nucleic Acids Res. 41(10) 5341-53. DOI: 10.1093/nar/gkt236, IF: 8.808

• Pevala V , Fricova D, Kunova N, Gajdosova J, Visacka K, Tomaska L, Nosek J, Krejci L, Kutejova E. (2013) Localization and biochemical characteristics of Mgm101 homologue from Candida parapsilosis. Yeast 30 (1) 140. IF: 1.742

• Sebesta M, Burkovics P, Juhasz S, Zhang S, Szabo JE, Haracska L, Krejci L (2013) Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans. DNA Repair (Amst). 12 (9) 691-8. DOI: 10.1016/j.dnarep.2013.05.001, IF: 3.362

• Burkovics P, Sebesta M, Sisakova A, Plault N, Szukacsov V, Robert T, Pinter L, Marini V, Kolesar P, Haracska L, Gangloff S, Krejci L (2013) Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis. The EMBO Journal 33 (2) 279-81. DOI: 10.1038/emboj.2013.9, IF: 10.748

• Burgess RC, Sebesta M, Sisakova A, Marini VP, Lisby M, Damborsky J, Klein H, Rothstein R, Krejci L (2013) The PCNA interaction protein box sequence in Rad54 is an integral part of its ATPase domain and is required for efficient DNA repair and recombination. PLoS One. Dec 20;8(12):e82630. DOI: 10.1371/journal.pone.0082630, IF: 3.534

2012

• Kolesar P, Sarangi P, Altmannova V, Zhao X, Krejci L. (2012) Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation. Nucleic Acids Res. 40 (16) 7831-7843. DOI: 10.1093/nar/gks484, IF: 8.278

• Marini V and Krejci L. (2012). Unwinding of synthetic replication and recombination substrates by Srs2. DNA Repair (Amst). 11(10): 789-98. DOI: 10.1016/j.dnarep.2012.05.007, IF: 4.274

2011

• Sebesta M, Burkovics P, Haracska L and Krejci L. (2011) Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities. DNA Repair (Amst). 10(6):567-76. DOI: 10.1016/j.dnarep.2011.03.003, IF: 4.135

2010

• Saponaro M, Callahan D, Zheng X, Krejci L, Haber J, Klein H and Liberi G. (2010) Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair. PLoS Genetics 6(2):e1000858 DOI: e1000858 10.1371/journal.pgen.1000858, IF: 9.543

• Altmannova V, Eckert-Boulet N, Arneric M, Kolesar P, Chaloupkova R, Damborsky J, Sung P, Zhao X, Lisby M and Krejci L (2010) Rad52 SUMOylation affects the efficiency of the DNA repair. Nucleic Acids Res. 38 (14): 4708-21. DOI: 10.1093/nar/gkq195, IF: 7.836

2009

• Matulova P, Marini V, Burgess RC, Sisakova A, Kwon Y, Rothstein R, Sung P, Krejci L. (2009) Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates. J Biol Chem. 284 (12):7733-7745. DOI: 10.1074/jbc.M806192200, IF: 5.328

• Colavito S, Macris-Kiss M, Seong C, Gleeson O, Greene EC, Klein HL, Krejci L, Sung P (2009) Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption. Nucleic Acids Res. 37 (20): 6754-64. DOI: 10.1093/nar/gkp748, IF: 7.479

• Burgess RC, Lisby M, Altmannova V, Krejci L, Sung P, Rothstein R (2009) Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo. J Cell Biol. 185(6):969-81. DOI: 10.1083/jcb.200810055, IF: 9.575

• Seong C, Colavito S, Kwon Y, Sung P, Krejci L (2009) Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediator and the Srs2 anti-recombinase. J Biol Chem. 284(36):24363-71. DOI: 10.1074/jbc.M109.032953, IF: 5.328

• Antony E, Tomko EJ, Xiao Q, Krejci L, Lohman TM, Ellenberger T. (2009) Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA. Mol Cell. 10;35(1):105-15. DOI: 10.1016/j.molcel.2009.05.026, IF: 14.608

• Prakash R, Satory D, Dray E, Papusha A, Scheller J, Kramer W, Krejci L, Klein H, Haber JE, Sung P, Ira G (2009) Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes Dev. 23(1):67-79. DOI: 10.1101/gad.1737809, IF: 12.075

2008

• Plate I, Hallwyl SC, Shi I, Krejci L, Müller C, Albertsen L, Sung P, Mortensen UH. (2008) Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity. J Biol Chem. 283(43):29077-85. DOI: 10.1074/jbc.M804881200, IF: 5.868

• Seong, C., Sehorn, M.G., Plate, I., Shi, I., Song, B., Chi, P., Mortensen, U., Sung, P., and Krejci, L. (2008). Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52. J Biol Chem. 283(18):12166-74. DOI: 10.1074/jbc.M800763200, IF: 5.52

2006

• Macris MA, Krejci L, Bussen W, Shimamoto A, Sung P. (2006) Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome. DNA Repair 5 (2): 172-180, DOI: 10.1016/j.dnarep.2005.09.005, IF: 5.868

• San Filippo J, Chi P, Sehorn MG, Etchin J, Krejci L, Sung P. (2006) Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide. J Biol Chem. 281(17):11649-57. DOI: 10.1074/jbc.M601249200, IF: 5.808

2005

• Papouli, E., Chen, S., Davies, A.A., Huttner, D., Krejci, L., Sung, P., Ulrich, H.D. (2005) Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol. Cell 19(1): 123-33. DOI: 10.1016/j.molcel.2005.06.001, IF: 14.971

• Chen L, Trujillo KM, Van Komen S, Roh DH, Krejci L, Lewis LK, Resnick MA, Sung P, Tomkinson AE. (2005) Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast. J Biol Chem. 280(4):2620-7. DOI: 10.1074/jbc.M410192200, IF: 6.355

• Prakash R, Krejci L, Van Komen S, Anke Schurer K, Kramer W, Sung P. (2005) Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3′ to 5′ DNA helicase. J Biol Chem. 280(9):7854-60. DOI: 10.1074/jbc.M413898200, IF: 5.854

2004

• Krejci L, Macris M, Li Y, Van Komen S, Villemain J, Ellenberger T, Klein H, Sung P. (2004) Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein. J Biol Chem., 279(22): 23193-9. DOI: 10.1074/jbc.M402586200, IF: 6.355

2003

• Van Komen, S., Reddy, M. S., Krejci, L., Klein, H. & Sung, P. (2003) ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2. J. Biol. Chem. 278:44331-7. DOI: 10.1074/jbc.M307256200, IF: 6.482

• Madsen LB, Petersen AH, Nielsen VH, Nissen PH, Duno M, Krejci L, Bendixen C, Thomsen B. (2003) Chromosome location, genomic organization of the porcine COL10A1 gene and model structure of the NC1 domain. Cytogenet Genome Res. 102 (1-4): 1424-8581. DOI: 10.1159/000075744, IF: 0.497

• Krejci, L., Van Komen, S., Li, Y., Villemain, J., Reddy, M. S., Klein, H., Ellenberger, T., Sung, P. (2003) DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature 423:305-9. Featured in Nature News & Views “Disruptive Influence” by Marco Foiani, (2003), 423:234-235. DOI: 10.1038/nature01577, IF: 30.979

2002

• Krejci, L., Song, B., Bussen, W., Rothstein, R., Mortensen, U., and Sung, P. (2002) Interaction with Rad51 is indispensable for recombination mediator function of Rad52. J. Biol. Chem. 277:40132-41. DOI: 10.1074/jbc.M206511200, IF: 6.696

2001

• Krejci, L., Damborsky, J., Thomsen, C., Duno, M., and Bendixen, C. (2001) Molecular dissection of interactions between Rad51 and members of the recombination-repair group. Mol. Cell. Biol. 21:966-976. DOI: 10.1128/MCB.21.3.966-976.2001, IF: 9.836

2000

• Duno, M., Thomsen, B., Westergaard, O., Krejci, L., and Bendixen, C. (2000) Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1. Mol. Gen. Genet. 264:89-97. IF: 2.462

• Krejci, L., Thomsen, B., Duno, M., Westergaard, O., and Bendixen, C. (2000) Homomeric interaction of the mouse Rad52 protein. Mol. Biol. Rep. 27:55-59. DOI: 10.1023/a:1007115032543, IF: 1.2

REVIEWS

1. Samadder P, Aithal R, Belan O, Krejci L. Cancer TARGETases: DSB repair as a pharmacological target. (2016) Pharmacol Ther. 161: 111-131. DOI: 10.1016/j.pharmthera.2016.02.007

2. Lenart P, Krejci L. DNA, the central molecule of aging. (2016) 786 (1-7). DOI: 10.1016/j.mrfmmm.2016.01.007

3. Lyakhovich A, Graifer, D, Stefanovie B, Krejci L. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. (2016) Biochim Biophys Acta 1865 (2) 184-189. DOI: 10.1016/j.bbcan.2016.02.006

4. Bartosova Z and Krejci L (2014). Nucleases in homologous recombination as targets for cancer therapy.FEBS Lett. 588 (15) 2446-2456. DOI: 10.1016/j.febslet.2014.06.010, IF: 3.169

5. Altmannova V, Kolesar, P, and Krejci L (2012) SUMO Wrestles with Recombination. Biomolecules. 2 (3), 350-375.

6. Krejci L, Altmannova V, Spirek M, and Zhao X (2012) Homologous recombination and its regulation. Nucleic Acids Res. 40 (13) 5795-818. DOI: 10.1093/nar/gks270, IF: 8.278

7. Marini, V, and Krejci, L (2010) Srs2: the “Odd-Job Man” in DNA repair. DNA Repair, 9 (3):268-75. DOI: 10.1016/j.dnarep.2010.01.007, IF: 4.293

8. Krejci, L, Chen, L, Van Komen, S, Sung, P, and Tomkinson, A (2003) Mending the break: two DNA double-strand break repair machines in eukaryotes. Prog. Nucl. Acid Res. & Mol. Biol. 74:159-201. DOI: 10.1016/S0079-6603(03)01013-4, IF: 6.544

9. Sung, P, Krejci, L, Van Komen, S & Sehorn, MG (2003) Rad51 recombinase and recombination mediators. J. Biol. Chem. 278:42729-32. DOI: 10.1074/jbc.R300027200, IF: 6.482

10. Krejci, L and Sung, P (2002) Of forks and ends. Trends Biochem. Sci. 27:225-226. DOI: 10.1016/S0968-0004(02)02083-2, IF: 14.398

11. Krejci, L and Sung, P (2002) RPA not that different from SSB. Structure 10:601-604. DOI: 10.1016/S0969-2126(02)00765-7, IF: 6.03

BOOK CHAPTERS

Marek Sebesta and Lumir Krejci: Chapter 4. Mechanism on Homologous Recombination. In: DNA Replication, Recombination, and Repair – Molecular Mechanisms and Pathology (eds. Fumio Hanaoka & Kaoru Sugasawa). Springer. 2016

PATENT FAMILIES

Damborsky J, Nikulenkov F, Sisakova A, Havel S, Krejci L, Carbain B, Brezovsky J, Daniel L, Paruch K. Pyrazolotriazines as Inhibitors of Nucleases. WO 2015/192817 A1.